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Incorporation ofl-leucine andd-glucosamine into skin fibroblasts derived from cystic fibrosis and normal individuals

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
44
Issue
1
Identifiers
DOI: 10.1016/0009-8981(73)90155-1
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Cultured skin fibroblasts from patients with diagnosed cystic fibrosis were compared with those from normal individuals in respect to incorporation of l-leucine or d-glucosamine into the subcellular components, to uptake of α-isobutyric acid and calcium, and to (Na +-K +)ATPase activity, etc. No significant difference which could be attributed to the disease-specific basic metabolic abnormality was demonstrated. Cystic fibrosis skin fibroblasts may not express the primary genetic defect at the level of generalized transport mechanism and overall protein metabolism.

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