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Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II

Authors
Journal
Genomics
0888-7543
Publisher
Elsevier
Volume
102
Issue
4
Identifiers
DOI: 10.1016/j.ygeno.2013.07.006
Keywords
  • Breast Cancer
  • Treatment
  • Eqtl
  • Gene Expression
  • Snp
  • Radiotherapy
  • Breast Cancer Survivors

Abstract

Abstract Introduction We investigated the effect of genetic variation on gene expression in blood from a cohort of BC survivors. Further, we investigated the associations that were specific for BC survivors by performing identical analyses for a group of healthy women and comparing the results. Methods eQTL analysis was performed for 288 BC survivors (full data set). Further, using a subset of the data, eQTL analyses were performed on 288 BC survivors and on 81 healthy women separately and results were compared. Results A large number of associations were observed for the BC survivors, and the expression of human leukocyte antigen genes was found associated with SNPs in 100 genes. The comparison analyses with healthy women revealed associations occurring specifically in BC survivors, and the genes showed enrichment for immune system processes. Conclusions The results suggest that the immune system has a different constitution in BC survivors compared to healthy women.

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