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Predicting the successful peripheral blood stem cell harvesting

Authors
Journal
Transfusion and Apheresis Science
1473-0502
Publisher
Elsevier
Volume
48
Issue
3
Identifiers
DOI: 10.1016/j.transci.2013.04.028
Disciplines
  • Medicine

Abstract

Abstract Several previously defined factors affecting the mobilization success include age, prior chemotherapy lines, exposure to myelotoxic agents, extended field radiotherapy and bone marrow infiltration with the primary disease. The purpose of this study was to retrospectively analyze the influence of the predictive factors for a successful peripheral stem cell mobilization. We enrolled a total of 145 patients into the study (non-Hodgkin lymphoma (n: 40), Hodgkin lymphoma (n: 36), myeloma (n: 64), solid tumors (n:5)) who received autologous stem cell transplantation between 2009 and 2012. In multivariate analysis only platelet count was found to be related with mobilization outcome (p<0.05). Knowing predictive factors for successful mobilization may be useful to define the best timing for mobilization and the most appropriate mobilizing agents for proper patient population.

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