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The effect of non-insulin-dependent diabetes on serum concentrations of tumor-associated carbohydrate antigens of CA19-9, CA-50, and sialyl SSEA-1 in association with the Lewis blood phenotype

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
190
Issue
3
Identifiers
DOI: 10.1016/0009-8981(90)90182-r
Keywords
  • Diabetes
  • Tumor Marker
  • Lewis Antigen
Disciplines
  • Medicine

Abstract

Abstract Serum concentrations of the tumor-associated carbohydrate antigens CA19-9, CA-50, and sialyl SSEA-1 were measured in non-insulin-dependent diabetic patients without diseases causing the elevation of those antigens, and the relationship to diabetic conditions was studied. The patients of the Lewis blood group phenotype of Le a (23%) had higher serum CA19-9, CA-50, and sialyl SSEA-1 than those of Le b (67%) and Le(−) (10%). Le a patients with high HbA1c (> 10%) had significantly higher serum CA19-9 and CA-50 than those with low HbA1c (≦ 7%). Le b patients with high HbA1c also had elevated CA19-9 and sialyl SSEA-1. In Le b patients, diabetic nephropathy was associated with increased CA19-9 levels. Diabetic retinopathy was also accompanied by high carbohydrate antigens in Le b patients, but the difference was not significant. Le b patients treated with sulfonylurea or insulin had increased CA19-9 and CA-50. The changes in serum concentrations of these carbohydrate antigens might have some relationship not only to the Lewis blood phenotype, but also to diabetes.

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