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Evaluation of hypervitaminosis A in the rat by measurement of tibial bone breaking strain

Authors
Journal
Journal of Pharmacological Methods
0160-5402
Publisher
Elsevier
Publication Date
Volume
11
Issue
2
Identifiers
DOI: 10.1016/0160-5402(84)90018-4
Keywords
  • Hypervitaminosis A
  • Etretinate
  • Isotretinoin

Abstract

Abstract Using etretinate as a model compound, the bone changes characteristic of hypervitaminosis A were evaluated in the rat in terms of tibial bone-breaking strain. Dose-related effects were observed in the dose range of 5–30 mg/kg p.o. for 15 days. The model proved a simple and precise means of assessing hypervitaminosis A in this species. Isotretinoin also showed a small but significant reduction in tibial breaking strain, but with a shallow dose-response curve in the range of 50–150 mg/kg.

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