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Hippocampal seizure-onset laterality can change over long timescales: A same-patient observation over 500 days

Authors
Journal
Epilepsy & Behavior Case Reports
2213-3232
Publisher
Elsevier
Volume
1
Identifiers
DOI: 10.1016/j.ebcr.2013.03.003
Keywords
  • Epilepsy
  • Seizure
  • Laterality
  • Shifting
  • Electrocorticography
  • Neurostimulation

Abstract

Abstract This study describes seizure laterality and localization changes over 500 consecutive days in a patient with bilateral temporal lobe epilepsy (BTLE) and implanted NeuroPace RNS™ System. During a continuous two-year time period, the RNS™ device stored 54 hippocampal electrocorticography (ECoG) seizures, which we analyzed to determine their distribution and time variance across hippocampi. We report nonrandom long-term seizure laterality and localization variations, especially in the first 200days postimplant, despite equivalent total seizure counts in both hippocampi. This case suggests that hippocampal seizures dynamically progress over extensive timescales.

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