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Hypoxic protection against fast neutrons of different energies—A review

Authors
Journal
European Journal of Cancer (1965)
0014-2964
Publisher
Elsevier
Publication Date
Volume
7
Identifiers
DOI: 10.1016/0014-2964(71)90009-0
Disciplines
  • Mathematics
  • Medicine

Abstract

Abstract The differences between the dependence of Oxygen Enhancement Ratio (OER) on fast neutron energy in P- 388 murine leukaemia cells, and the lack of effect of neutron energy upon OER reported in human kidney-derived T- 1 cells correlate well (perhaps fortuitously) with differences in responses of the same cells to irradiation with monoenergetic track-segments of beams of deuterons and alpha-particles whose ionization densities (LET) are known. However, irradiation of the P- 388 tumour cells with collimated beams of fast neutrons at 10 cm depth in a tissue-equivalent phantom yields OER values lower than predicted by consideration of average LET and relatively independent of neutron energy. For irradiation from a planar array of neutron-emitting 25 2 Cf sources in a tissue-equivalent holder simulating a brachytherapy implant, the OER is disappointingly high (2 · 0), although still significantly lower than for irradiation with 2 26 Ra gamma rays in the same geometry.

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