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B-1 cell response in immunity against parasites

Authors
  • Novaes e Brito, Ronni Rômulo1
  • dos Santos Toledo, Mayte2
  • Labussiere, Gabriela Martins2
  • Dupin, Talita Vieira2
  • de Campos Reis, Natasha Ferraz2
  • Perez, Elizabeth Cristina3
  • Xander, Patricia2, 4
  • 1 Centro Universitário São Camilo, São Paulo, Brazil , São Paulo (Brazil)
  • 2 Universidade Federal de São Paulo Campus Diadema, Departamento de Ciências Farmacêuticas, Diadema, Brazil , Diadema (Brazil)
  • 3 Universidade Paulista, Pós Graduação em Patologia Ambiental e Experimental, São Paulo, Brazil , São Paulo (Brazil)
  • 4 Universidade Federal de São Paulo campus Diadema, Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Farmacêuticas, Rua São Nicolau, 210, Unidade José Alencar, Prédio de Pesquisa, 4° andar, Diadema, São Paulo, Brazil , São Paulo (Brazil)
Type
Published Article
Journal
Parasitology Research
Publisher
Springer-Verlag
Publication Date
Apr 02, 2019
Volume
118
Issue
5
Pages
1343–1352
Identifiers
DOI: 10.1007/s00436-019-06211-2
Source
Springer Nature
Keywords
License
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Abstract

The peritoneal cavity has a microenvironment capable of promoting proliferation, differentiation, and activation of the resident cells and recruitment of blood cells through the capillary network involved in the peritoneum. Among the cells found in the peritoneal cavity, B-1 cells are a particular cell type that contains features that are not very well defined. These cells differ from conventional B lymphocytes (B-2) by phenotypic, functional, and molecular characteristics. B-1 cells can produce natural antibodies, migrate to the inflammatory focus, and have the ability to phagocytose pathogens. However, the role of B-1 cells in immunity against parasites is still not completely understood. Several experimental models have demonstrated that B-1 cells can affect the susceptibility or resistance to parasite infections depending on the model and species. Here, we review the literature to provide information on the peculiarities of B-1 lymphocytes as well as their interaction with parasites.

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