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Longitudinal study of the cellular response to Pf155/RESA and circumsporozoite protein in Madagascar

Authors
Journal
Immunology Letters
0165-2478
Publisher
Elsevier
Publication Date
Volume
25
Identifiers
DOI: 10.1016/0165-2478(90)90120-f
Keywords
  • Plasmodium Falciparum
  • Cellular Response
  • Pf155/Resa
  • Circumsporozoite Protein
Disciplines
  • Biology

Abstract

Abstract In a community follow-up conducted in the Central Highlands of Madagascar, the cellular responses to synthetic peptides from the immunodominant regions of Pf155/RESA and the repeat region of the circumsporozoite protein were studied. Seasonal variations of the T cell response were measured at the individual level; the relationship between this response and the presence of parasites in blood was assessed; the question of the possible protective value of the lymphocyte proliferation in presence of a specific antigen was addressed.

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