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Kinetics of poliovirus replication in HeLa cells infected by isolated RNA

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
52
Issue
2
Identifiers
DOI: 10.1016/0006-291x(73)90760-2

Abstract

Abstract Under conditions with the least toxicity for cells compatible with an optimal sensitizing effect for RNA infection, 47% of HeLa cells can be infected by viral RNA. Both RNA and virus infective centers produce identical amounts, i.e. 2000 PFU of progeny virus per infective center and both incorporate 3H uridine in equal quantities. After infection with an effective multiplicity of ten PFU of virus or RNA, virus maturation occurs thirty minutes earlier in RNA-infected cells as compared to virus-infected cells.

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