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Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
13
Issue
19
Identifiers
DOI: 10.1016/s0960-894x(03)00665-6
Disciplines
  • Design
  • Pharmacology

Abstract

Abstract Based on literature structures, we proposed a pharmacophore for NOP receptor ligands and used it as a guide for the design of a focused piperidine library and an optimization library. Potent NOP receptor agonists and antagonists were obtained from these libraries as well as a few potent, mu selective agonists.

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