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A chemical method of labelling oligodeoxyribonucleotides with biotin: A single step procedure using a solid phase methodology

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
30
Issue
23
Identifiers
DOI: 10.1016/s0040-4039(00)99410-3

Abstract

Abstract Protected D(+)-biotin methylesters 3 were reduced to the corresponding alcohols 4 and phosphitylated with chloromethoxymorpholinophosphine. The resulting phosphoramidites 5 were used on a commercial DNA synthesiser to biotinylate synthetic DNA.

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