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B and T cell markers of bone marrow and peripheral blood lymphoid cells in patients with paraproteinaemia.

Authors
  • Husz, S
  • Krizsa, F
  • Dobozy, A
  • Hunyadi, J
  • Simon, N
Type
Published Article
Journal
Acta haematologica
Publication Date
Jan 01, 1977
Volume
57
Issue
6
Pages
321–330
Identifiers
PMID: 70148
Source
Medline
License
Unknown

Abstract

Studies have been carried out on B and T cells in bone marrow and peripheral blood from patients with paraproteinaemia. The peripheral blood of patients with multiple myeloma showed a significant increase of B cells, mainly lymphoid cells bearing immunoglobulins corresponding to the paraproteins, while in patients with benign monoclonal gammopathy only a slight increase of B cells and a moderate decrease of T cells have been found. As to the bone marrow, the B cell population was significantly raised in patients with multiple myeloma, but it remained unchanged in patients with benign monoclonal gammopathy. Our findings may offer a new possibility to distinguish between these two diseases and provide further data to their pathogenesis.

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