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B cells: no longer the nondominant arm of multiple sclerosis.

Authors
  • Klawiter, Eric C
  • Cross, Anne H
Type
Published Article
Journal
Current neurology and neuroscience reports
Publication Date
May 01, 2007
Volume
7
Issue
3
Pages
231–238
Identifiers
PMID: 17488589
Source
Medline
License
Unknown

Abstract

The role B cells and humoral immunity play in multiple sclerosis (MS) is continually evolving. Recent discoveries include advances in lesion classification, identification of B cell clonal expansion in the central nervous system with evidence of antigen targeting, identification of chemokines in MS lesions, and expansion of information on the roles of autoantibodies and complement. Strong indications are accumulating that a greater degree of humoral dysfunction may lead to worsened long-term prognosis in MS. Effects of established MS treatments on B cells and their products have been further defined. Treatments that specifically target B cells are being implemented and hold promise.

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