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B cell tolerance: lessons from transplantation.

Authors
  • Cascalho, Marilia1
  • 1 Mayo Clinic College of Medicine, 200 First Street SW, Medical Sciences 2-113, Rochester, MN 55905, USA. [email protected]
Type
Published Article
Journal
Current drug targets. Cardiovascular & haematological disorders
Publication Date
Jun 01, 2005
Volume
5
Issue
3
Pages
271–275
Identifiers
PMID: 15975039
Source
Medline
License
Unknown

Abstract

Given the ability of the B cell compartment to acquire tolerance to self we cannot explain why spontaneous humoral tolerance does not arise following transplantation. Here we review the fundamental mechanisms of B cell tolerance that operate in development and direct the reader to possible mechanisms that may explain how B cell tolerance fails to develop following transplantation.

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