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B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell chronic lymphocytic leukemia.

Authors
  • Marti, Gerald E
  • Carter, Patricia
  • Abbasi, Fatima
  • Washington, Glennelle C
  • Jain, Nisha
  • Zenger, Vincent E
  • Ishibe, Naoko
  • Goldin, Lynn
  • Fontaine, Laura
  • Weissman, Nancy
  • Sgambati, Maria
  • Fauget, Guy
  • Bertin, Pablo
  • Vogt, Robert F Jr
  • Slade, Barbara
  • Noguchi, Philip D
  • Stetler-Stevenson, M A
  • Caporaso, Neil
Type
Published Article
Journal
Cytometry. Part B, Clinical cytometry
Publication Date
Mar 01, 2003
Volume
52
Issue
1
Pages
1–12
Identifiers
PMID: 12599176
Source
Medline
License
Unknown

Abstract

Individual components of BCML and other B-cell abnormalities were observed in almost half of the apparently unaffected individuals. Our findings suggested that BCML may be an early detectable abnormality in BCLL. The spectrum of some of these observed abnormalities suggested the involvement of different B-cell subpopulations or different pathways in clonal evolution. Population-based, longitudinal studies will be required to determine the incidence of BCML and other B-cell abnormalities and their relation to disease progression in BCLL and other closely related B-cell lymphoproliferative disorders.

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