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Azulene analogs of pharmacological agents III: acute toxicity and local anesthetic activity of azulylamides and azulenecarboxamides.

Authors
  • Doukas, P H
  • Speaker, T J
  • Thompson, R S
Type
Published Article
Journal
Journal of pharmaceutical sciences
Publication Date
Jan 01, 1975
Volume
64
Issue
1
Pages
158–161
Identifiers
PMID: 1079533
Source
Medline
License
Unknown

Abstract

This paper describes the acute toxicity of two azulylamides and six azulenecarboxamides and the nerve conduction-inhibiting properties of some of these compounds. The azulene derivatives are compared to their benzenoid prototypes, lidocaine and procainamide, as part of a continuing investigation of the biological properties of nonbenzenoid aromatic compounds.

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