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Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012-2013.

Authors
  • Alvarez, Josep
  • Godoy, Pere
  • Plans-Rubio, Pedro
  • Camps, Neus
  • Carol, Monica
  • Carmona, Gloria
  • Solano, Ruben
  • Rius, Cristina
  • Minguell, Sofia
  • Barrabeig, Irene
  • Sala-Farré, Maria R
  • Rodriguez, Raquel
  • Garcia-Cenoz, Manuel
  • Muñoz-Almagro, Carmen
  • Dominguez, Angela
Type
Published Article
Journal
Emerging Infectious Diseases
Publisher
Centers For Disease Control and Prevention
Publication Date
Nov 01, 2020
Volume
26
Issue
11
Pages
2678–2684
Identifiers
DOI: 10.3201/eid2611.181418
PMID: 33079034
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We retrospectively assessed the effectiveness of azithromycin in preventing transmission of pertussis to a patient's household contacts. We also considered the duration between symptom onset in the primary patient and azithromycin administration. We categorized contacts into 4 groups: those treated within <7 days, 8-14 days, 15-21 days, and >21 days after illness onset in the primary patient. We studied 476 primary index patients and their 1,975 household contacts, of whom 4.5% were later identified as having pertussis. When contacts started chemoprophylaxis within <21 days after the primary patient's symptom onset, the treatment was 43.9% effective. Chemoprophylaxis started >14 days after primary patient's symptom onset was less effective. We recommend that contacts of persons with pertussis begin chemoprophylaxis within <14 days after primary patient's symptom onset.

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