Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion
- Authors
- Type
- Published Article
- Journal
- Immunology Letters
- Publisher
- European Federation of Immunological Societies. Published by Elsevier B.V.
- Publication Date
- Sep 28, 2020
- Volume
- 228
- Pages
- 83–85
- Identifiers
- DOI: 10.1016/j.imlet.2020.09.008
- PMID: 33002511
- PMCID: PMC7521214
- Source
- PubMed Central
- Keywords
- License
- Unknown
Abstract
Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effective for type 1 interferon induction. High-dose glucosamine administration up-regulates O-GlcNAcylation by increasing the cellular pool of UDP -N- acetylglucosamine. Hence, it is proposed that joint administration of azithromycin and high-dose glucosamine, early in the course of RNA virus infections, may interact in a complementary fashion to aid their control by enhancing type 1 interferon induction
