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Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion

Authors
  • DiNicolantonio, James J.1
  • Barroso-Aranda, Jorge2
  • McCarty, Mark F.3
  • 1 Mid America Heart Institute, Kansas City, MO, United States
  • 2 Clinica Libre de Adicciones, Tijuana, B.C, Mexico
  • 3 Catalytic Longevity Foundation, United States
Type
Published Article
Journal
Immunology Letters
Publisher
European Federation of Immunological Societies. Published by Elsevier B.V.
Publication Date
Sep 28, 2020
Volume
228
Pages
83–85
Identifiers
DOI: 10.1016/j.imlet.2020.09.008
PMID: 33002511
PMCID: PMC7521214
Source
PubMed Central
Keywords
License
Unknown

Abstract

Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effective for type 1 interferon induction. High-dose glucosamine administration up-regulates O-GlcNAcylation by increasing the cellular pool of UDP -N- acetylglucosamine. Hence, it is proposed that joint administration of azithromycin and high-dose glucosamine, early in the course of RNA virus infections, may interact in a complementary fashion to aid their control by enhancing type 1 interferon induction

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