Affordable Access

Azasordarins: Susceptibility of Fluconazole-Susceptible and Fluconazole-Resistant Clinical Isolates of Candida spp. to GW 471558

Authors
  • Manuel Cuenca-Estrella
  • Emilia Mellado
  • Teresa M. Díaz-Guerra
  • Araceli Monzón
  • Juan L. Rodríguez-Tudela
Publisher
American Society for Microbiology
Publication Date
Jun 01, 2001
Source
PMC
Keywords
License
Unknown

Abstract

The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candida spp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreased susceptibility to azoles. Candida krusei, Candida parapsilosis, Candida lusitaniae, and Candida guilliermondii are resistant to GW 471558 in vitro (MICs, >128 μg/ml).

Report this publication

Statistics

Seen <100 times