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Awake Reactivation of Prior Experiences Consolidates Memories and Biases Cognition.

Authors
  • Tambini, Arielle1
  • Davachi, Lila2
  • 1 Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.
  • 2 Department of Psychology, Columbia University, New York, NY, USA; Nathan Kline Institute, Orangeburg, NY, USA. Electronic address: [email protected]
Type
Published Article
Journal
Trends in cognitive sciences
Publication Date
Oct 01, 2019
Volume
23
Issue
10
Pages
876–890
Identifiers
DOI: 10.1016/j.tics.2019.07.008
PMID: 31445780
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

After experiences are encoded into memory, post-encoding reactivation mechanisms have been proposed to mediate long-term memory stabilization and transformation. Spontaneous reactivation of hippocampal representations, together with hippocampal-cortical interactions, are leading candidate mechanisms for promoting systems-level memory strengthening and reorganization. While the replay of spatial representations has been extensively studied in rodents, here we review recent fMRI work that provides evidence for spontaneous reactivation of nonspatial, episodic event representations in the human hippocampus and cortex, as well as for experience-dependent alterations in systems-level hippocampal connectivity. We focus on reactivation during awake post-encoding periods, relationships between reactivation and subsequent behavior, how reactivation is modulated by factors that influence consolidation, and the implications of persistent reactivation for biasing ongoing perception and cognition. Copyright © 2019 Elsevier Ltd. All rights reserved.

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