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An avian model for the study of acute hemolytic anemia in the domestic fowl (Gallus domesticus).

Authors
  • Datta, K
  • Soni, J L
  • Datta, I C
Type
Published Article
Journal
Biomedica biochimica acta
Publication Date
Jan 01, 1990
Volume
49
Issue
7
Pages
607–611
Identifiers
PMID: 2282066
Source
Medline
License
Unknown

Abstract

Acute hemolytic anemia was experimentally induced in chickens with the oxidant chemical phenylhydrazine. From results of the graded doses trial, subcutaneously injected 6 mg/100 g body weight single dose was designated as standardised. The anemic response, characterized by marked reductions in hemoglobin, packed cell volume and total erythrocyte count, was perceptible on day 1 post-injection. Peak anemia was observed on day 3. Compensatory erythropoiesis was discernible on day 5. The hematological profile indicated near complete recovery on day 11 post-injection. This avian model is proposed for study of the basic mechanisms of hemolytic anemia in chickens.

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