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AVIA 3.0: Interactive Portal for Genomic Variant and Sample Level Analysis.

Authors
  • Reardon, Hue V1
  • Che, Anney1
  • Luke, Brian T1
  • Ravichandran, Sarangan1
  • Collins, Jack R1
  • Mudunuri, Uma S1
  • 1 Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, operated by Leidos Biomedical, Frederick, MD, USA.
Type
Published Article
Journal
Bioinformatics (Oxford, England)
Publication Date
Dec 08, 2020
Identifiers
DOI: 10.1093/bioinformatics/btaa994
PMID: 33289511
Source
Medline
Language
English
License
Unknown

Abstract

The Annotation, Visualization and Impact Analysis (AVIA) is a web application combining multiple features to annotate and visualize genomic variant data. Users can investigate functional significance of their genetic alterations across samples, genes, and pathways. Version 3.0 of AVIA offers filtering options through interactive charts and by linking disease relevant data sources. Newly incorporated services include gene, variant and sample level reporting, literature and functional correlations among impacted genes, comparative analysis across samples and against data sources such as TCGA and ClinVar, and cohort building. Sample and data management is now feasible through the application, which allows greater flexibility with sharing, reannotating and organizing data. Most importantly, AVIA's utility stems from its convenience for allowing users to upload and explore results without any a priori knowledge or the need to install, update, and maintain software or databases. Together, these enhancements strengthen AVIA as a comprehensive, user-driven variant analysis portal. AVIA is accessible online at https://avia-abcc.ncifcrf.gov. Published by Oxford University Press 2020.

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