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The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation.

Authors
Type
Published Article
Journal
Journal of Neuroscience
1529-2401
Publisher
Society for Neuroscience
Publication Date
Volume
35
Issue
32
Pages
11399–11414
Identifiers
DOI: 10.1523/JNEUROSCI.0345-15.2015
PMID: 26269646
Source
Medline
License
Unknown

Abstract

The formation of the axon insulating and supporting myelin sheath by differentiating oligodendrocytes (OLGs) in the CNS is considered an essential step during vertebrate development. In addition, loss and/or dysfunction of the myelin sheath has been associated with a variety of neurologic diseases in which repair is limited, despite the presence of progenitor cells with the potential to differentiate into myelinating OLGs. This study characterizes the autotaxin-lysophosphatidic acid signaling axis as a modulator of OLG differentiation in vivo in the developing zebrafish and in vitro in rodent OLGs in culture. These findings provide novel insight into the regulation of developmental myelination, and they are likely to lead to advancing studies related to the stimulation of myelin repair under pathologic conditions.

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