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Auto-Regulation of Leptin Neurobiology

Authors
  • LeDuc, Charles A.1
  • Leibel, Rudolph L.1
  • 1 Division of Molecular Genetics (Pediatrics) and the Naomi Berrie Diabetes Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA
Type
Published Article
Journal
Cell metabolism
Publication Date
Oct 01, 2019
Volume
30
Issue
4
Pages
614–616
Identifiers
DOI: 10.1016/j.cmet.2019.09.006
PMID: 31577926
PMCID: PMC7413296
Source
PubMed Central
License
Unknown

Abstract

The clinical use of the hormone leptin, a key regulator of food intake, to treat the most common instances of obesity has so far failed. In this issue, Zhao et al. (2019) report that, paradoxically, reducing leptin levels in obese mice increases their sensitivity to the concentrations that remain, and leads to reductions in weight gain, thus suggesting why these earlier trials may have failed and possibly a new approach to treating obesity.

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