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[Autoradiographic research on RNA biosynthesis in renal tissue in the early period of corrosive sublimate-induced necronephrosis].

Authors
Type
Published Article
Journal
Biulleten' eksperimental'noĭ biologii i meditsiny
Publication Date
Volume
106
Issue
11
Pages
632–635
Identifiers
PMID: 2461752
Source
Medline

Abstract

Study of 3H-uridine autoradiographs in semithin methacrylate renal sections of white rats showed pronounced decrease of uridine mark in all cellular types of renal tissue following 24 hours after the administration of 0.5 mg corrosive sublimate per 100 g bw. The period was marked by the development of anuria in animals. 48 hours later increase of uridine mark level in renal cortical substance was observed. Epithelial cells being contiguous with necrosed zone of non- and partially damaged but kept-alive urinary small canals became hypertrophic and synthesized RNA actively preceding their mitotic division.

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