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Autophagy and virus infection

Authors
  • Jia, Pingdong
Type
Published Article
Journal
Infection International
Publisher
De Gruyter Open
Publication Date
Apr 10, 2018
Volume
6
Issue
4
Pages
124–128
Identifiers
DOI: 10.2478/ii-2018-0001
Source
De Gruyter
Keywords
License
Yellow

Abstract

Autophagy is a highly conserved pathway for physiological metabolism. Bilayer vesicles transport their contents to lysosomes for degradation. Autophagy is therefore a means of removing intracellular viruses and other pathogens in mammalian cells. However, the role of autophagy in virus infection is complex. Several viruses have developed a way to escape autophagy-dependent degradation and replicate themselves through autophagy. This article summarizes the fundamental mechanism and function of autophagy and its role in infection with viruses such as HIV, HTLV-1, and other retroviruses.

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