Affordable Access

deepdyve-link
Publisher Website

An automatic solid-phase synthesis of peptaibols.

Authors
  • Hjørringgaard, Claudia U
  • Pedersen, Jan M
  • Vosegaard, Thomas
  • Nielsen, Niels Chr
  • Skrydstrup, Troels
Type
Published Article
Journal
The Journal of Organic Chemistry
Publisher
American Chemical Society
Publication Date
Feb 06, 2009
Volume
74
Issue
3
Pages
1329–1332
Identifiers
DOI: 10.1021/jo802058x
PMID: 19108634
Source
Medline
License
Unknown

Abstract

An automated approach to peptaibols using microwave-assisted solid-phase peptide synthesis is demonstrated with a combination of HBTU and acid fluoride mediated couplings for normal and alpha,alpha-dialkylated amino acids, respectively. The method is utilized for the automated synthesis of several full-length peptaibols, including alamethicin, tylopeptin, ampullosporin, bergofungin, cervinin, trikoningin, trichogin, and peptaibolin, reducing both synthesis time and costs significantly as compared to other approaches. Furthermore, the use of noncommercially available reagents is minimized.

Report this publication

Statistics

Seen <100 times