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An automated system for fast transfer and injection of hyperpolarized solutions

Authors
  • Ceillier, Morgan
  • Cala, Olivier
  • El Daraï, Théo
  • Cousin, Samuel
  • Stern, Quentin
  • Guibert, Sylvie
  • Elliott, Stuart
  • Bornet, Aurélien
  • Vuichoud, Basile
  • Milani, Jonas
  • Pages, Christophe
  • Eshchenko, Dmitry
  • Kempf, James
  • Jose, Catherine
  • Lambert, Simon Auguste
  • Jannin, Sami
Publication Date
Dec 01, 2021
Identifiers
DOI: 10.1016/j.jmro.2021.100017
OAI: oai:HAL:hal-03412640v1
Source
HAL-Descartes
Keywords
Language
English
License
Unknown
External links

Abstract

Dissolution dynamic nuclear polarization (dDNP) has become a hyperpolarization method of choice for enhancing nuclear magnetic resonance (NMR) signals. Nuclear spins are polarized in solid frozen samples (in a so-called polarizer) that are subsequently dissolved and transferred to an NMR spectrometer for high sensitivity detection. One of the critical challenges of dDNP is that it requires both a fast transfer to limit nuclear spin relaxation losses as well as stability to guarantee high resolution (no bubbles nor turbulences). Here we describe the design, construction and performances of such a transfer and injection system, that features a 5 m/s speed and sub-Hz spectral resolution upon arrival at the detection spot. We demonstrate the use of such a system for inter-magnet distances of up to 10 m.

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