Affordable Access

deepdyve-link
Publisher Website

Automated liver lesion detection in 68Ga DOTATATE PET/CT using a deep fully convolutional neural network

Authors
  • Wehrend, Jonathan1
  • Silosky, Michael1
  • Xing, Fuyong2
  • Chin, Bennett B.1
  • 1 University of Colorado School of Medicine Anschutz Medical Campus,
  • 2 University of Colorado Anschutz Medical Campus,
Type
Published Article
Journal
EJNMMI Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 02, 2021
Volume
11
Identifiers
DOI: 10.1186/s13550-021-00839-x
PMID: 34601660
PMCID: PMC8487415
Source
PubMed Central
Keywords
Disciplines
  • Original Research
License
Unknown

Abstract

Background Gastroenteropancreatic neuroendocrine tumors most commonly metastasize to the liver; however, high normal background 68Ga-DOTATATE activity and high image noise make metastatic lesions difficult to detect. The purpose of this study is to develop a rapid, automated and highly specific method to identify 68Ga-DOTATATE PET/CT hepatic lesions using a 2D U-Net convolutional neural network. Methods A retrospective study of 68Ga-DOTATATE PET/CT patient studies ( n = 125; 57 with 68Ga-DOTATATE hepatic lesions and 68 without) was evaluated. The dataset was randomly divided into 75 studies for the training set (36 abnormal, 39 normal), 25 for the validation set (11 abnormal, 14 normal) and 25 for the testing set (11 abnormal, 14 normal). Hepatic lesions were physician annotated using a modified PERCIST threshold, and boundary definition by gradient edge detection. The 2D U-Net was trained independently five times for 100,000 iterations using a linear combination of binary cross-entropy and dice losses with a stochastic gradient descent algorithm. Performance metrics included: positive predictive value (PPV), sensitivity, F1 score and area under the precision–recall curve (PR-AUC). Five different pixel area thresholds were used to filter noisy predictions. Results A total of 233 lesions were annotated with each abnormal study containing a mean of 4 ± 2.75 lesions. A pixel filter of 20 produced the highest mean PPV 0.94 ± 0.01. A pixel filter of 5 produced the highest mean sensitivity 0.74 ± 0.02. The highest mean F1 score 0.79 ± 0.01 was produced with a 20 pixel filter. The highest mean PR-AUC 0.73 ± 0.03 was produced with a 15 pixel filter. Conclusion Deep neural networks can automatically detect hepatic lesions in 68Ga-DOTATATE PET. Ongoing improvements in data annotation methods, increasing sample sizes and training methods are anticipated to further improve detection performance. Supplementary Information The online version contains supplementary material available at 10.1186/s13550-021-00839-x.

Report this publication

Statistics

Seen <100 times