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Automated anti-Mullerian hormone measurement: data review to provide insights and interpretation.

Authors
  • Homburg, R1
  • Rao, U1
  • Malamas, F1
  • Palouki, P1
  • Gudi, A1
  • Shah, A1
  • Brooks, S2
  • Drakeley, A2
  • Faye, S3
  • 1 Homerton Fertility Centre, Homerton University NHS Foundation Trust Hospital, London, UK.
  • 2 Hewitt Fertility Centre, Liverpool Women's Hospital, Liverpool, UK.
  • 3 Independent Scientific Consultant, Leeds, UK.
Type
Published Article
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Publication Date
Jun 01, 2021
Volume
37
Issue
6
Pages
511–514
Identifiers
DOI: 10.1080/09513590.2020.1785419
PMID: 32603200
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

AMH results were pooled and a table with 2.5 and 97.5 percentiles for each age group constructed. Based on Youden index, the optimal cut off for low responders (0-3 eggs), was 5.5 pmol/l (87% sensitivity, 55% specificity) and for high responders (>15 eggs) 15.6 pmol/l (78% sensitivity, 57% specificity). AMH correlated with number of eggs collected (r = 0.48) and clinical pregnancies (r = 0.14), (p < .0001). The table of AMH levels measured using the Access 2 fully automated immunoassay system according to age may be used as a reference and cutoff levels for high and poor responders are clearly defined to help tailor controlled ovarian stimulation, maximizing efficiency and ensuring patient safety. The use of a random access automated immunoassay system means that blood sampled on arrival can produce an AMH result in 40 mins by the time the subject enters the doctor's clinic together with other relevant endocrine markers.

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