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Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: a new cell-based therapy

Authors
  • García-Olmo, Damian1
  • García-Arranz, Mariano1
  • García, Lourdes Gómez1
  • Cuellar, Eduardo Serna1
  • Blanco, Ignacio Fernández1
  • Prianes, Luis Asensio1
  • Montes, José Antonio Rodríguez1
  • Pinto, Francisca Lima1
  • Marcos, Dolores Herreros1
  • García-Sancho, Luis1
  • 1 Autonomous University of Madrid, Department of General Surgery, La Paz University Hospital, Paseo de la Castellana 261, Madrid, 28046, Spain , Madrid
Type
Published Article
Journal
International Journal of Colorectal Disease
Publisher
Springer-Verlag
Publication Date
May 20, 2003
Volume
18
Issue
5
Pages
451–454
Identifiers
DOI: 10.1007/s00384-003-0490-3
Source
Springer Nature
Keywords
License
Yellow

Abstract

Background and aimsRectovaginal fistulas in patients with Crohn's disease are difficult to resolve, and surgical failure is very frequent. Recent studies have shown that adult stem cells extracted from certain tissues, such as adipose tissue, can develop into different tissues, such as muscle.Patient and methodsWe report here the case of a young patient with Crohn's disease who had a recurrent rectovaginal fistula that was treated by autologous stem-cell transplantation with a lipoaspirate as the source of stem cells.ResultsAlthough Crohn's disease is the worst condition for a surgical approach in cases of rectovaginal fistula, we observed good closure. Since the surgical procedure 3 month ago the patient has not experienced vaginal flatus or fecal incontinence through her vagina. Thus our treatment seems to be effective.ConclusionCell transplantation to overcome healing problems is a new surgical tool, and careful evaluation of this new modality may provide an opportunity to define a new era in the treatment of surgical challenges associated with healing disorders. Ethical and safety items do not seem to be critical problems using autologous stem cells.

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