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Autologous platelet-rich plasma in the treatment of refractory wounds in cutaneous leukocytoclastic vasculitis complicated with hypertension (grade 2 moderate risk): A case report.

Authors
  • Yi, Zhongmei1
  • Song, Nali1
  • Chen, Zhou2
  • Fan, Yahan1
  • Liu, Yueling3
  • Zhang, Bin4
  • 1 Department of Blood Transfusion, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. , (China)
  • 2 Department of Blood Transfusion, QianJiang Central Hospital, Chongqing, China. , (China)
  • 3 Department of Dermatology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. , (China)
  • 4 Department of Blood Transfusion, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Transfusion and Apheresis Science
Publisher
Elsevier
Publication Date
May 06, 2021
Pages
103157–103157
Identifiers
DOI: 10.1016/j.transci.2021.103157
PMID: 33972173
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cutaneous leukocytoclastic vasculitis is an inflammatory variant of vasculitis with a variety of causes that only affects the skin. Its pathological manifestations include neutrophil infiltration and nuclear fragmentation. Clinically, it is characterised by a pleomorphic rash, including erythema, purpuric skin lesions, reticulocytosis, necrosis and ulceration. Once formed, local ulcerations are very difficult to heal. A 46-year-old female was diagnosed with cutaneous leukocytoclastic vasculitis. The patient's legs exhibited ulcers with a black eschar on the surface. The largest wound was 4.5 × 4.0 cm and the deepest wound was 1.7 × 1.8 × 1.0 cm. The ulcers had been present for 6 months and did not exhibit signs of healing. Treatment was commenced with platelet-rich plasma, and the wounds healed within 1 month. Topical application of autologous platelet-rich plasma gel exerts beneficial effects in cutaneous leukocytoclastic vasculitis with regard to wound size reduction, and it induces granulation tissue formation. Platelet-rich plasma may represent a safe and cost-effective treatment for managing cutaneous wound healing to reduce the length of the recovery period. Copyright © 2021. Published by Elsevier Ltd.

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