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Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease.

Authors
  • Dietz, Allan B1
  • Dozois, Eric J2
  • Fletcher, Joel G3
  • Butler, Greg W4
  • Radel, Darcie4
  • Lightner, Amy L2
  • Dave, Maneesh5
  • Friton, Jessica6
  • Nair, Asha7
  • Camilleri, Emily T8
  • Dudakovic, Amel8
  • van Wijnen, Andre J8
  • Faubion, William A9
  • 1 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address: [email protected]
  • 2 Department of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota.
  • 3 Department of Radiology, Mayo Clinic, Rochester, Minnesota.
  • 4 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
  • 5 Division of Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio.
  • 6 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
  • 7 Department of Biomedical Statistics and Information, Mayo Clinic, Rochester, Minnesota.
  • 8 Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
  • 9 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address: [email protected]
Type
Published Article
Journal
Gastroenterology
Publication Date
Jul 01, 2017
Volume
153
Issue
1
Identifiers
DOI: 10.1053/j.gastro.2017.04.001
PMID: 28400193
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell-coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

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