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Autoimmune T cells lured to a FASL web of death by MSCs.

Authors
Type
Published Article
Journal
Cell Stem Cell
Publisher
Elsevier
Volume
10
Issue
5
Pages
485–485
Identifiers
DOI: 10.1016/j.stem.2012.04.013
Source
Murphy Lab dermatology-ucdavis
License
Unknown

Abstract

Achieving immune tolerance through cell transplantation is a promising approach for treating autoimmune disease. In this issue of Cell Stem Cell, Akiyama et al. (2012) demonstrate that human and mouse mesenchymal stem cells can induce immune suppression by attracting and killing autoreactive T cells, which stimulates TGFb production by macrophages and generates regulatory T cells.

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