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Autocrine growth factors and cancer.

Authors
  • Sporn, M B
  • Roberts, A B
Type
Published Article
Journal
Nature
Publication Date
Jan 01, 1985
Volume
313
Issue
6005
Pages
745–747
Identifiers
PMID: 3883191
Source
Medline
License
Unknown

Abstract

The ability of cancer cells to produce and to respond to their own growth factors (autocrine secretion) has become a central concept linking oncogene and growth factor research. Oncogenes confer growth factor autonomy on cells not only by coding directly for autocrine peptide growth factors or their receptors, but also by amplifying the mitogenic signals generated by a growth factor at its receptor. Antagonists of positive autocrine growth factors can inhibit growth of cancer cells in experimental animals. Recently identified negative autocrine growth factors might themselves control aberrant cell growth.

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