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Autoantibody against a 58 kD molecule in a patient with neutropenia and NK cell deficiency.

Authors
  • Witte, T
  • Bode, F M
  • Hammer, M
  • Deicher, H
  • Schmidt, R E
Type
Published Article
Journal
British journal of haematology
Publication Date
Mar 01, 1996
Volume
92
Issue
3
Pages
565–570
Identifiers
PMID: 8616018
Source
Medline
License
Unknown

Abstract

A patient with Evans' syndrome is described who developed intermittently an immunocytopenia consisting of autoimmune neutropenia and natural killer (NK) cell deficiency. During this time an autoantibody binding to a 58 kD antigen expressed on granulocytes, activated NK cells and Epstein-Barr virus (EBV) transformed B cells was present. Incubation of activated NK cells and NK cell clones with the autoantibody leads to a significant inhibition of NK activity. Therefore the autoantibody may detect a functionally important activation molecule.

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