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Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis.

Authors
  • Lisa, Antonella
  • Monti, Daniela
  • Franceschi, Claudio
  • Scovassi, Anna Ivana
Type
Published Article
Journal
Gerontology
Publication Date
Jan 01, 2009
Volume
55
Issue
4
Pages
427–429
Identifiers
DOI: 10.1159/000213652
PMID: 19372636
Source
Medline
License
Unknown

Abstract

Taking into account the role of PARP-1 in DNA damage and apoptosis, the data are compatible with Grabar's hypothesis, which proposed several decades ago that 'autoreactive antibodies represent a physiological system for disposing the products of metabolism and catabolism', thereby helping to attain longevity.

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