Taking into account the role of PARP-1 in DNA damage and apoptosis, the data are compatible with Grabar's hypothesis, which proposed several decades ago that 'autoreactive antibodies represent a physiological system for disposing the products of metabolism and catabolism', thereby helping to attain longevity.
Other sources for this publication
Autoantibodies to Poly(ADP-Ribose) Polymerase in Centenarians: A Reappraisal of Grabar’s Hypothesis
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/19372636