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Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease.

Authors
  • Söderholm, J D
  • Olaison, G
  • Peterson, K H
  • Franzén, L E
  • Lindmark, T
  • Wirén, M
  • Tagesson, C
  • Sjödahl, R
Type
Published Article
Journal
Gut
Publication Date
Mar 01, 2002
Volume
50
Issue
3
Pages
307–313
Identifiers
PMID: 11839706
Source
Medline
License
Unknown

Abstract

The tight junctions in the non-inflamed distal ileum of Crohn's disease were more reactive to luminal stimuli, possibly mediated via disturbed cytoskeletal contractility. This could contribute to the development of mucosal neoinflammation in Crohn's disease.

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