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Augmentation of coronary responsiveness to serotonin at the site of X-ray-induced intimal thickening in miniature pigs.

Authors
  • Mitsuoka, W
  • Egashira, S
  • Tagawa, H
  • Kuga, T
  • Hayashi, Y
  • Yamada, A
  • Tomoike, H
  • Nakamura, M
  • Takeshita, A
Type
Published Article
Journal
Cardiovascular research
Publication Date
Aug 01, 1995
Volume
30
Issue
2
Pages
246–254
Identifiers
PMID: 7585812
Source
Medline
License
Unknown

Abstract

These results indicate that X-irradiation augments the coronary vasoconstrictor responses to autacoids, predominantly to serotonin, and that this augmentation is accompanied by enhanced intimal thickening. Serotonin-induced hypercontraction after X-irradiation resulted mainly from the hyperreactivity of medial smooth muscle.

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