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Auditory responses in cochlear implant users with and without GJB2 deafness.

Authors
  • Propst, Evan Jon1
  • Papsin, Blake C
  • Stockley, Tracy L
  • Harrison, Robert V
  • Gordon, Karen A
  • 1 Department of Otolaryngology-Head and Neck Surgery and the Molecular Genetics Laboratory, The Hospital for Sick Children, Toronto, Ontario, Canada. [email protected]
Type
Published Article
Journal
The Laryngoscope
Publication Date
February 2006
Volume
116
Issue
2
Pages
317–327
Identifiers
PMID: 16467727
Source
Medline
License
Unknown

Abstract

Results suggest more consistent spiral ganglion survival along the length of the cochlea in GJB2-related HL as compared with non-GJB2-related HL, which appears to involve a decreasing gradient of spiral ganglion survival from the apex to the base of the cochlea. Our findings support our premise that in GJB2-related HL, dysfunction of gap junctions likely occurs to a similar degree in the apical and basal regions of the cochlea. This knowledge might be used to customize implantable devices for patients with HL in the future.

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