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An audit of the management of elderly patients with glioblastoma in the UK: have recent trial results changed treatment?

Authors
  • Chong, Ming Yao1
  • Lorimer, Cressida F2
  • Mehta, Shaveta3
  • Ibrahim, Ehab3
  • Brock, Juliet2
  • McBain, Catherine3
  • McLoone, Philip4
  • Chalmers, Anthony J5
  • 1 NHS Greater Glasgow & Clyde, Glasgow, Scotland, G51 4TF, UK
  • 2 Brighton & Sussex University Hospitals NHS Trust, Brighton, England, BN2 5BB, UK
  • 3 The Christie NHS Foundation Trust, Manchester, England, M20 4BX, UK
  • 4 Institute of Health & Wellbeing, University of Glasgow, Glasgow, Scotland, G12 8RZ, UK
  • 5 Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, G12 0YN, UK
Type
Published Article
Journal
CNS Oncology
Publisher
Future Medicine
Publication Date
Dec 10, 2019
Volume
8
Issue
4
Identifiers
DOI: 10.2217/cns-2019-0017
PMID: 31818127
PMCID: PMC6974914
Source
PubMed Central
License
Green

Abstract

Aim: We investigated uptake of short-course chemo-radiotherapy and compared outcomes with other treatment schedules in elderly patients with glioblastoma (GBM). Methods: Patients aged 65 or over with a diagnosis of GBM were identified from an 18-month period from three centers in the UK. The primary end point of this study was overall survival from the date of diagnosis. Results: The analysis included 210 patients. Overall median survival was 5.0 months. Approximately 31.9% of patients received combined chemoradiation; multivariate analysis showed that patients who received standard chemoradiation were at a reduced risk of death than those receiving hypofractionated chemoradiation. Discussion: In this retrospective study, patients treated with standard chemoradiation experienced better outcomes than patients receiving hypofractionated chemoradiation. Patient selection likely contributed to these findings.

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