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[email protected] nanostructures: a novel photothermal conversion agent for cancer therapy.

Authors
Type
Published Article
Journal
Nanoscale
2040-3364
Publisher
The Royal Society of Chemistry
Publication Date
Volume
6
Issue
7
Pages
3670–3678
Identifiers
DOI: 10.1039/c3nr06841b
PMID: 24566522
Source
Medline

Abstract

Due to aspect ratio dependent localized surface plasmon resonance (SPR), gold nanorods (Au NRs) can be tuned to have a strong absorption in the near infrared region (NIR) and convert light to heat energy, which shows promises in cancer photothermal therapy. In this study, we introduced another more efficient NIR photothermal agent, Au nanorods coated with a shell of Pt nanodots ([email protected] nanostructures). After surface modification with Pt dots, the [email protected] nanostructure became a more efficient photothermal therapy agent as verified both in vitro and in vivo. To clarify the mechanism, we assessed the interaction between the MDA-MB-231 cells with [email protected] or Au NRs. Results showed that the slightly higher uptake and the reduced sensitivity of the longitudinal SPR band on the intracellular aggregate state may contribute to the better photothermal efficiency for [email protected] NRs. The theoretical studies further confirmed that the [email protected] nanostructure itself exhibited better photothermal efficiency compared to Au NRs. These advantages make the [email protected] nanostructure a more attractive and effective agent for cancer photothermal therapy than general Au NRs.

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