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Atypical pulmonary thrombosis caused by a toxic cyanobacterial peptide.

Authors
  • Slatkin, D N
  • Stoner, R D
  • Adams, W H
  • Kycia, J H
  • Siegelman, H W
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Jun 24, 1983
Volume
220
Issue
4604
Pages
1383–1385
Identifiers
PMID: 6407109
Source
Medline
License
Unknown

Abstract

Parenteral injection into mice of a toxic pentapeptide isolated from the cyanobacterium Microcystis aeruginosa induced thrombocytopenia, pulmonary thrombi, and hepatic congestion. The lethality of the toxin was unaffected by several anticoagulants. The acute liver damage that follows injection of the toxin has been attributed to direct action on liver cells but may be due to hypoxemia, heart failure, and shock.

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