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Atypical prefrontal cortical responses to joint/non-joint attention in children with autism spectrum disorder (ASD): A functional near-infrared spectroscopy study.

Authors
Type
Published Article
Journal
Biomedical Optics Express
2156-7085
Publisher
The Optical Society
Publication Date
Volume
6
Issue
3
Pages
690–701
Identifiers
DOI: 10.1364/BOE.6.000690
PMID: 25798296
Source
Medline
Keywords
License
Unknown

Abstract

Autism spectrum disorder (ASD) is a neuro-developmental disorder, characterized by impairments in one's capacity for joint attention. In this study, functional near-infrared spectroscopy (fNIRS) was applied to study the differences in activation and functional connectivity in the prefrontal cortex between children with autism spectrum disorder (ASD) and typically developing (TD) children. 21 ASD and 20 TD children were recruited to perform joint and non-joint attention tasks. Compared with TD children, children with ASD showed reduced activation and atypical functional connectivity pattern in the prefrontal cortex during joint attention. The atypical development of left prefrontal cortex might play an important role in social cognition defects of children with ASD.

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