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Atypical antipsychotic-like effects of the dopamine D3 receptor agonist, (+)-PD 128,907.

Authors
  • Witkin, J
  • Gasior, M
  • Acri, J
  • Beekman, M
  • Thurkauf, A
  • Yuan, J
  • DeBoer, P
  • Wikström, H
  • Dijkstra, D
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Apr 24, 1998
Volume
347
Issue
2-3
Identifiers
PMID: 9741997
Source
Medline
License
Unknown

Abstract

Anti-schizophrenia agents with improved efficacy and side-effect profiles are required. A dopamine D3 receptor agonist, R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3- b]-1,4-oxazin-9-ol HCl ((+)-PD 128,907), displayed an atypical antipsychotic profile comparable to that of clozapine. (+)-PD 128,907 blocked stereotypy produced by dizocilpine (MK-801) at 12-fold lower doses than those affecting apomorphine-induced stereotypes in mice and did not produce catalepsy. These effects of (+)-PD 128,907 were stereospecific and were blocked by a D3 antagonist. These data suggest a role for D3 receptors in antipsychotic drug action.

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