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Attenuation of renal ischemia-reperfusion injury in rats by allopurinol and prostaglandin E1.

Authors
  • Gupta, P C1
  • Matsushita, M
  • Oda, K
  • Nishikimi, N
  • Sakurai, T
  • Nimura, Y
  • 1 First Department of Surgery, Nagoya University School of Medicine, Japan. , (Japan)
Type
Published Article
Journal
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
Publication Date
Jan 01, 1998
Volume
30
Issue
2
Pages
102–107
Identifiers
PMID: 9565743
Source
Medline
License
Unknown

Abstract

50 Sprague-Dawley rats were used to study the effect of allopurinol and prostaglandin E1 (PGE1) on renal ischemia-reperfusion injury. They underwent left renal ischemia for 1 h and reperfusion. A right nephrectomy was performed, and 5 groups were made. Group AP received allopurinol 50 mg/kg and PGE1 20 micrograms/kg; group A, allopurinol; group P, PGE1; group C, control, and group S, sham group. Five animals from each group were used to study renal functions and 5 for renal histology. The serum creatinine values were lower in the treatment groups compared to the controls on days 1-3 and 7 (p < 0.05). The blood urea nitrogen values showed a similar trend. Maximum histological damage was seen in group C, followed by groups A, P and AP, in this order. We conclude that allopurinol and PGE1 attenuate renal ischemia-reperfusion injury in rats.

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