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Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's Immune Modulation Therapy.

Authors
  • Nolan, Yvonne
  • Minogue, Aedín
  • Vereker, Emily
  • Bolton, Anthony E
  • Campbell, Veronica A
  • Lynch, Marina A
Type
Published Article
Journal
Neuroimmunomodulation
Publication Date
Jan 01, 2002
Volume
10
Issue
1
Pages
40–46
Identifiers
PMID: 12207162
Source
Medline
License
Unknown

Abstract

Systemic injection of lipopolysaccharide (LPS) blocks the expression of long-term potentiation in the hippocampus of the rat. This is coupled with increased IL-1beta concentration and c-Jun NH(2)-terminal kinase activity, as well as an increase in the number of cells displaying apoptotic characteristics in the hippocampus. Vasogen's Immune Modulation Therapy (IMT) is a procedure involving intramuscular administration of syngeneic blood which has been exposed ex vivo to elevated temperature, oxidation and ultraviolet light. We report that Vasogen's IMT significantly abrogates these LPS-induced effects with a concomitant increase in the concentration of the anti-inflammatory cytokine IL-10. These data suggest that Vasogen's IMT may play a protective role against the deleterious effects of immune insults in the brain.

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