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Attenuation of immune complex nephritis in NZB/WF1 mice by a prostacyclin analogue.

Authors
  • Utsunomiya, Y
  • Ogura, M
  • Kawamura, T
  • Mitarai, T
  • Maruyama, N
  • Sakai, O
Type
Published Article
Journal
Clinical and experimental immunology
Publication Date
Mar 01, 1995
Volume
99
Issue
3
Pages
454–460
Identifiers
PMID: 7882569
Source
Medline
License
Unknown

Abstract

Although prostaglandins have been shown to inhibit the evolution of the nephritis in NZB/W mice, the mechanisms of this effect are unknown. To characterize such inhibition, we injected the prostacyclin (PGI2) analogue, beraprost, into NZB/W mice, using 0.5 mg, 1.0 mg or 5.0 mg beraprost/kg body weight of test animals three times in 1 week when the mice were 2 months old. Evaluation included measurement of urine albumin excretion, serological parameters and splenic T cell subset, as well as examination of renal histology by light and fluorescence microscopy. Mice given beraprost showed a marked decrease in urine albumin excretion and in glomerular hypercellularity compared with untreated controls. Maximal beneficial effects occurred when the dose was 5.0 mg/kg of beraprost. These effects correlated with a reduction of immune complex deposition in glomeruli. In addition, beraprost reduced serum levels of immunoglobulins and anti-double-stranded DNA antibodies, and decreased the number of helper (L3T4+) T cells in splenocytes. These results indicate that beraprost attenuates the nephritis of NZB/W mice, and that the source of this effect is the reduced production of autoantibodies and deposition of immune complexes in glomeruli.

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