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Attention-deficit/hyperactivity disorder and brain metabolites from proton magnetic resonance spectroscopy: a systematic review and meta-analysis protocol.

Authors
  • Vidor, Marcos Vinícius1, 2
  • Panzenhagen, Alana Castro1, 3
  • Martins, Alexandre Ribeiro4
  • Cupertino, Renata Basso1, 5
  • Bandeira, Cibele Edom1, 6
  • Rohde, Luis Augusto2, 7
  • Rovaris, Diego Luiz1, 8
  • Bau, Claiton Henrique Dotto1, 6
  • Grevet, Eugênio Horácio1, 2
  • 1 Programa de Transtornos de Déficit de Atenção/Hiperatividade em Adultos (ProDAH-A), Centro de Pesquisa Clínica (CPC), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre , RS , Brazil . , (Brazil)
  • 2 Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento , Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre , RS , Brazil . , (Brazil)
  • 3 Programa de Pós-Graduação em Ciências Biológicas: Bioquímica , UFRGS , Porto Alegre , RS , Brazil . , (Brazil)
  • 4 Serdil - Clínica de Radiologia e Diagnóstico de Imagem , Porto Alegre , RS , Brazil . , (Brazil)
  • 5 Department of Psychiatry , University of Vermont , Burlington . VT , USA .
  • 6 Departamento de Genética , Instituto de Biociências , UFRGS , Porto Alegre , RS , Brazil . , (Brazil)
  • 7 Instituto Nacional de Psiquiatria do Desenvolvimento (INPD), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Porto Alegre , RS , Brazil . , (Brazil)
  • 8 Instituto de Ciências Biomédicas , Departamento de Fisiologia e Biofísica , Universidade de São Paulo (USP), São Paulo , SP , Brazil . , (Brazil)
Type
Published Article
Journal
Trends in psychiatry and psychotherapy
Publication Date
Jan 01, 2021
Volume
43
Issue
1
Pages
1–8
Identifiers
DOI: 10.47626/2237-6089-2019-0111
PMID: 33681905
Source
Medline
Language
English
License
Unknown

Abstract

Despite major advances in the study of the brain, investigations on neurochemistry in vivo still lack the solid ground of more established methods, such as structural and functional magnetic resonance imaging. Proton magnetic resonance spectroscopy (MRS) is a technique that might potentially fill in this gap. Nevertheless, studies using this approach feature great methodological heterogeneity, such as varying voxel of choice, differences on emphasized metabolites, and absence of a standardized unit. In this study, we present a methodology for creating a systematic review and meta-analysis for this kind of scientific evidence using the prototypical case of attention-deficit/hyperactivity disorder. Systematic review registration: International Prospective Register of Systematic Reviews (PROSPERO), CRD42018112418.

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